Compromised KCC2 function leads to dysregulation of Cl− homeostasis and is implicated in developmental, acquired, and degenerative neurological disorders, among them epilepsy, neuropathic pain, autism spectrum disorders, schizophrenia, and following brain trauma, documented in several in vivo and in vitro studies (Payne et al., 2003; Boulenguez et al., 2010; Kahle et al., 2014; Puskarjov et al., 2014; Merner et al., 2015). This evidence concerns the gene SLC12A5 and epilepsy.