The 10 most significant genes included AP2B1 [FDR P = 2.5 × 10−6, log2(FC) = −1.6], also significant in cluster B4 [FDR P = 0.021, log2(FC) = .02], a gene involved in endocytosis and autophagy that plays a role in dendritogenesis41 and has been implicated in Alzheimer’s disease.42DNAJB9, a gene involved in cellular response, was significantly lower in cluster C2 [FDR P = 1.7 × 10−9, log2(FC) = −1.5]. This evidence concerns the gene AP2B1 and early-onset autosomal dominant Alzheimer disease.