KLHL15 and Intellectual disability: Among these, KLHL15 (tissue: log2FC = −2.1, FDR P = 0.009; blood: log2FC = −1.5, FDR P = 0.03) has been observed to be partially deleted in a case study of an individual with a severe intellectual disability, epilepsy and anomalies of cortical development.39 Additionally, the mitochondrial gene Vdac2 (tissue: log2FC = −0.92, FDR P = 0.03; blood: log2FC = −1.33, FDR P = 0.04) is associated with refractory epilepsy in pharmacoresistant rats.40