However, PIGB, which is implicated in hereditary epileptic seizures, is among the top 10 genes driving the separation of cluster B4 (FDR P = 0.003, log2(FC) = 1.02).37,38 Notably, PIGB was also significantly altered in cluster C2 (FDR P = 0.048, log2(FC) = −0.783). The gene discussed is PIGB; the disease is Seizure.