CD4 and hepatocellular carcinoma: By comparing immune cell infiltration between HCC and controls, we found that CD4+ naive T cells, CD4+ memory activated T cells, follicular helper T cells (Tfh), regulatory T cells (Tregs), macrophage M0, myeloid dendritic cell resting, myeloid dendritic cell activated, and mast cell activated were higher infiltrated in HCC, while plasma B cells, gamma delta T cells, monocyte, macrophage M2, mast cell resting, eosinophil, and neutrophil were lower infiltrated in HCC (Figure 6C).