The expression of candidate genes in paired tumors tissues and adjacent non-tumor tissues of GSE174570 showed that BPGM was significantly higher expressed in HCC than in controls, and HK3, ENO3, ALDH1B1, ALDH9A1, ADH6, ADH1A, ADH1B, PCK1, ALDOB, FBP1, ALDH2, and PCK2 were significantly lower expressed in HCC (Figure 3F). The gene discussed is PCK2; the disease is hepatocellular carcinoma.