Tumor-specific CD8+ T cells isolated from patients in “non-major pathological response (non-MPR)” were often highly expressed with genes associated with T cell dysfunction (TOX2, CTLA-4, TIM-3, and CD39), while patients with MPR have higher expression of genes associated with memory (IL7R and TCF7) and effector function (GZMK). The gene discussed is TOX2; the disease is neoplasm.