Additionally, C. butyricum was reported to prevent acute experimental colitis in mice by inducing IL-10-producing macrophages in inflamed mucosa (22), and Clostridium cluster IV and XIVa are highly effective in decreasing inflammation via decreased production of IL-12 and INF-γ and increased production of anti-inflammatory cytokine IL-10 (23). The gene discussed is IL10; the disease is colitis.