In terms of IDH-wild-type glioblastoma in adults < 70 years of age, our recommendations are as follows: postoperative RT with concurrent and adjuvant temozolomide is recommended for MGMT-methylated glioblastoma and MGMT-unmethylated glioblastoma, and for patients with unknown MGMT methylation status. This evidence concerns the gene IDH2 and glioblastoma.