Thus, depression (OR = 6.252, P = 0.029), NIHSS score (OR = 1.24, P = 0.011), albumin level (OR = 0.841, P = 0.032), WMH at the GCC (OR = 3.1, P = 0.033), and frontal WMH volume (OR = 1.18, P = 0.04) were used to construct a cognitive prediction scale. The gene discussed is ALB; the disease is major depressive disorder.