The genes regulated in all pathways, Cyp1a1, Cyp1a2, Cyp2a1, Cyp2b1, Cyp4a8, Cyp2c11, Rdh16, Alox15, Ephx2, Sult2a1, and Acox2, were the potential targets for ZYP treatment of cholestasis. The gene discussed is RDH16; the disease is cholestasis.