GPT and cholestasis: As shown in Figures 1A−I, the serum levels of ALT, AST, ALP, γ-GT, DBIL, TBIL, TBA, TC, and TG in the rats in the cholestasis Model group were significantly higher than those in the Control group, while both ZYP_L and ZYP_H could significantly reduce the above indexes, showing a similar trend of action with UDCA.