The genes regulated in all pathways, Cyp1a1, Cyp1a2, Cyp2a1, Cyp2b1, Cyp4a8, Cyp2c11, Rdh16, Alox15, Ephx2, Sult2a1, and Acox2, were the potential targets for ZYP treatment of cholestasis. Here, CYP1A2 is linked to cholestasis.