Indeed, myositis induced by ICIs with concomitant myocarditis may represent a specific subtype characterized by markedly inflammatory muscle biopsies and activation of the type 2 interferon pathway, while the features of ICIs-induced dermatomyositis are the presence of anti-TIF1γ autoantibodies and overexpression of type 1 interferon-inducible genes (Pinal-Fernandez et al., 2023). This evidence concerns the gene TRIM33 and myocarditis.