A similar situation was observed with mSEPT9, where SEPT9 gene methylation was detected in a significant percentage of gastric cancer, head and neck squamous carcinoma, hepatic carcinoma, esophageal cancer, lung cancer, cholangiocarcinoma, and bladder cancer patients.45, 73, 74, 75, 76. This evidence concerns the gene SEPTIN9 and cholangiocarcinoma.