Although VDR is upregulated by the CML-driven gene BCR::ABL1 via transcriptional activation or protein stability that is dependent on the corresponding mutations, inhibiting VDR is sufficient to inhibit CML cell proliferation driven by BCR::ABL1 independent of its mutations in vitro and in vivo. The gene discussed is VDR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.