We then utilized a CML mouse model to assess the impact of VDR deletion on the disease, in which VDR-KO or WT BM was transduced with BCR::ABL1 and then transplanted into irradiated recipient mice (referred to as WT-CML and KO-CML mice) (Figure 4A). The gene discussed is VDR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.