We established a similar CML mouse model with an IM-resistant BCR::ABL1T315I mutation (referred to as CMLT315I mice) (Figure 5A) and found that VDR deletion significantly enhanced the survival of CMLT315I mice, which died 20 days after model establishment (Figure 5B), even in secondary transplanted mice (Supplementary Figure S5). Here, VDR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.