More importantly, unlike rapamycin, RMC-6272 can rescue early neurodevelopmental phenotypes such as proliferation and neurite outgrowth in TSC1−/− NPCs (Fig. 6 and [24]), raising the question whether 4E-BP1-dependent translation could be essential for some of the neurodevelopmental phenotypes in TSC and other mTORC1-activated neurodevelopmental disorders. Here, TSC1 is linked to neurodevelopmental disorder.