HMGB1 and neoplasm: Notably, among those 67 proteins, we found HMGB1 (high mobility group protein B1) (Fig. 3S) which, in addition to its role as a nuclear non-histone protein is involved in the regulation of transcription and chromatin remodeling, has a critical role as a DAMP that can be secreted outside a cell and participate in the activation of tumor cell repopulation [5, 27].