Mutations in SF3B1 are the most common across multiple tumor types, mainly found in myelodysplastic syndrome [71, 72] and other hematologic malignancies, uveal melanoma and breast cancer [73, 74], where its high mutational frequency altered the capacity of the spliceosome to recognize the pre-RNA pattern [25, 75]. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.