Through the production of growth factors (for example G-CSF and GM-CSF) and the production of inflammatory cytokines, including IL-6, IL-1β, and IL-17 (neutrophil diversity and plasticity in tumor progression and therapy), tumor cells and tumor niche regulate the development, maturation, and release from the bone marrow of neutrophils, which result in peripheral neutrophilia [28, 29]. Here, CSF2 is linked to neoplasm.