SHBG and deep vein thrombosis: With outcome data from the Finnish database, the results showed a significant causal effect of SHBG on VTE (P = 0.0258) and PE (P = 0.0028) but not on DVT, which is consistent with the primary two-sample MR analyses, with the difference being that BT also showed a significant causal effect on PE (P = 0.0445).