SHBG and Thromboembolism: However, a recent MR study observed a positive association between endogenous testosterone, genetically predicted by mutations in the JMJD1C gene region, and thromboembolism (VTE, arterial embolism, and thrombosis) (OR: 2.09, 95% CI: 1.27−3.46) in men, whereas no such association was found in women, and no association was observed between endogenous testosterone, genetically predicted by mutations in the SHBG gene region, and thromboembolism [45].