GFPT1 and lung cancer: Shimizu et al. also demonstrated that IL-8 stimulation of lung cancer cells enhances glucose uptake and the expression of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux in the HBP, resulting in increased protein O-GlcNAcylation [51].