INS and atherosclerosis: Additionally, 11 enriched pathways with the most significant differences between CON and CFE were identified, including “cholesterol metabolism,” “necroptosis,” “fat digestion and absorption,” “regulation of lipolysis in adipocytes,” “lipid and atherosclerosis,” “sphingolipid signaling pathway,” “insulin resistance,” “thermogenesis,” “sphingolipid metabolism,” “glycerolipid metabolism,” and “vitamin digestion and absorption” (Fig. 5F).