Interestingly, intraperitoneal administration of recombinant IL-6 protein in mice injected with MTV/TM-011 cells and adipocytes-Grem2 accelerated primary tumor growth compared to vehicle-treated group [mean ± SD (mm3): 148.78 ± 34.16 (MTV/TM-011 + adipocytes-Grem2_vehicle) vs. 249.55 ± 97.8 (MTV/TM-011 + adipocytes-Grem2_IL-6], six mice in MTV/TM-011 + adipocytes-Grem2_vehicle; five mice in MTV/TM-011 + adipocytes-Grem2_IL-6) (Fig. 6a, b). Here, GREM2 is linked to neoplasm.