Mice injected with MTV/TM-011 cells and adipocytes-Grem2 developed smaller primary tumors than mice injected with MTV/TM-011 cells and adipocytes-mock, resulting in a dramatic reduction in tumor volume [mean ± SD (mm3): 333.07 ± 103.87 (MTV/TM-011 + adipocytes-mock_vehicle) vs. 148.78 ± 34.16 (MTV/TM-011 + adipocytes-Grem2_vehicle), six mice/each group]. Here, GREM2 is linked to neoplasm.