EZH2 and cancer: In addition to its well-documented action as a competitively endogenous RNA (ceRNA) sponging miRNAs in human cancers [62], SNHG15 was reported to act in the nucleus in concert with EZH2 (Enhancer of zeste homolog 2), which is known to catalyze repressive trimethylation at histone 3 (H3K27me3) [63].