Wang et al. [13] reported that local extrahepatic metastasis, vascular infiltration, lymph node metastasis, tumor diameter > 5.5 cm, carcinoembryonic antigen level > 2.5 μg/L, and CA19-9 level > 41.2 U/mL were independent risk factors for postoperative recurrence and death in patients with intrahepatic cholangiocarcinoma. The gene discussed is CEACAM5; the disease is neoplasm.