Our recent study confirmed that TRPV4 and glial fibrillary acidic protein (GFAP) are synchronously upregulated in human hippocampal tissues from TLE patients and a 4-aminopyridine (4-AP)-induced epilepsy mice, and also explored the functional activity of TRPV4 promotes the reactivity of astrocytes [18]. Here, GFAP is linked to epilepsy.