HOTAIR and breast cancer: In addition, it is interesting to know that jumonji domain containing 6 (JMJD6) and bromodomain-containing protein 4 (BRD4) can be recruited to the HOTAIR promoter region to promote HOTAIR expression in breast cancer and glioblastoma multiforme [32, 33], and the JMJD6–BRD4 complex can modulate the expression of genes [34].