CD8A and neoplasm: Furthermore, we examined the tumor infiltrating CD8 + TILs and PMN-MDSC population by microscope and found that combination treatment of CN133 and anti-PD-1 antibody has been shown to alter the tumor microenvironment not only by reducing PMN-MDSC cell population but also significantly enhancing CD8 + TIL infiltration, comparing with CN133 or anti-PD-1 single treatment group in C57BL/J6 xenografts mice model (Fig. 5D, E).