In our study, we first analyzed the expression level of P2RY6 from the perspective of pan-cancer, and found that compared with normal tissues, the expression level of P2RY6 in a variety of cancer tissues was significantly higher, and the results of Kaplan–Meier analysis and univariate Cox regression analysis showed that the poor prognosis of patients was closely correlated with the high expression of P2RY6, so we concluded that the high expression of P2RY6 in most tumors may not be conducive to the survival of patients with related tumors. This evidence concerns the gene P2RY6 and cancer.