In addition, it is worth noting that when we explored the potential relationship between P2RY6 and immunomodulators, we found that the expression of this gene was positively related to a variety of immune activators and immunosuppressants, which means that P2RY6 may have a synergistic effect with other checkpoint members, thus playing a specific role in the regulation of tumor immune microenvironment. The gene discussed is P2RY6; the disease is neoplasm.