The mRNA and protein expression level of MMP9 had a significant increase after treatment with LPS in the Raw264.7, quercetin and naringenin could significantly decrease the mRNA and protein expression level of MMP9 (Fig. 7 C, D and Fig. 8), suggesting that lowering the expression of MMP9 might be the therapeutic effect of quercetin and naringenin in the treatment of ASCVD. Here, MMP9 is linked to atherosclerosis.