Some germline mutations, such as BAP1, are very powerful and may cause mesothelioma and other malignancies in the absence of environmental exposure to asbestos or to other carcinogens [20], others, may cause mesothelioma prevalently when associated with environmental exposure to asbestos or other carcinogenic fibers [3, 18, 21]. This evidence concerns the gene BAP1 and mesothelioma.