Drugs that inhibit HMGB1 directly (such as BoxA or monoclonal antibodies) or indirectly (such as aspirin [39] or ethyl pyruvate [40]) inhibit the growth of mesothelioma in mice and the growth of human mesothelioma cell lines in tissue culture [35, 38, 41, 42]. This evidence concerns the gene HMGB1 and mesothelioma.