Approximately 60–70% of mesotheliomas contain inactivating BAP1 mutations, which can be detected using an integrated genomic approach or simply by absence of BAP1 nuclear staining, since almost 100% of BAP1 inactivating mutations cause the loss of the nuclear localization signal located at the carboxy-terminus of the BAP1 protein [61]. This evidence concerns the gene BAP1 and mesothelioma.