As for the biological reasons that cause the improved survival of mesothelioma patients carrying BAP1 mutations, two very recent discoveries shed some light on this puzzling issue: (1) Louw et al., reported that biallelic inactivating BAP1 mutations increase susceptibility to chemotherapy [59]; and (2) we discovered that BAP1 deubiquitylates and stabilizes HIF-1α. This evidence concerns the gene BAP1 and mesothelioma.