A recent study has indicated that the lack of innate inflammatory signaling in tumors leads to the inability to induce transcription factor-regulated functional effector differentiation, further impairing effector function and induced TOX expression and multiple other negative regulators of T cell signaling and function via persistent tumor antigen/TCR stimulation and/or other negative regulatory signals, ultimately leading to dysfunction of tumor-specific CD8 + T cells even before undergoing cell division [55]. The gene discussed is TOX; the disease is neoplasm.