TSPAN7 and clear cell renal carcinoma: As early as September 2012, Wuttig D determined that TSPAN7 is a promising prognostic marker for clear cell renal cell carcinoma and indicated that patients with higher expression of the TSPAN7 gene or those with TSPAN7-positive blood vessels in both cores of tissue microarray studies had significantly longer DFS and tumor-specific survival (TSS) [17].