Numerous studies have shown that PYCR1 is closely related to the prognosis of various cancers such as bladder cancer, pancreatic ductal adenocarcinoma, renal adenocarcinoma, gastric cancer, prostate cancer, hepatocellular carcinoma, colorectal cancer, etc. Platelet-derived growth subunit A (PDGFA) plays a key role in the development of glioblastoma (GBM). The gene discussed is PDGFA; the disease is hepatocellular carcinoma.