RB1 and metastatic malignant neoplasm in the lymph nodes: It could be seen that patients with positive lymph nodes had a higher risk score than those with lymph node metastasis negative via the Wilcox test, which meant that a higher risk score indicated a worse prognosis; whereas risk scores were not significantly different between the presence and absence of FGFR3, P53, RB1, or Ras mutation, distant metastasis, high grade (Fig. 7E, J).