Together with three control viruses, Ad-Apoptin (Ad-VP3), Ad-hTERTp-E1A (Ad-T), and Ad-Mock, a dual cancer-specific oncolytic ADV called Ad-Apoptin-hTERTp-E1A (Ad-VT) were constructed with the Apoptin and hTERT promoter. This evidence concerns the gene DHTKD1 and cancer.