MTOR and neoplasm: The phosphoinositide 3-kinases (PI3K)/AKT pathway, consisting of PI3K, phosphatase and tensin homologue (PTEN), AKT (known as protein kinase B), and the mechanistic target of rapamycin (mTOR), is one of the most important pathways that regulates cell death, proliferation, motility, metabolism, and tumor vascular growth and maintenance, known as angiogenesis [13, 14].