SLC5A2 and chronic kidney disease: We are of the opinion that the larger effects of empagliflozin on cardiovascular death in EMPA-REG OUTCOME [37], and the larger effects on non-cardiovascular death in DAPA-CKD compared to other SGLT-2 inhibitor trials [5, 38] are more likely represent the play of chance or be caused by factors other than minor differences in the biological action of different SGLT-2 inhibitors.