In 2021, the UK Kidney Association (UKKA) Clinical Practice Guideline: SGLT-2 Inhibition in Adults with Kidney Disease Working Group published a Clinical Practice Guideline on the use of SGLT-2 inhibitors in adults with kidney disease in order to facilitate this, with emphasis on relevant large-scale randomised evidence for the efficacy and safety of SGLT-2 inhibition. Here, SLC5A2 is linked to kidney disorder.