GPX4 and ischemia: Pan et al. also revealed that targeting ferroptosis was a promising therapeutic strategy for lung ischemia–reperfusion injury (Pan et al. 2022) Our study showed that in LPS-induced ALI, the iron concentration in lung tissue was significantly increased, ferroptosis-related Gpx4 and GSH were significantly decreased, lipid peroxidation was significantly increased, and the ferroptosis inhibitor Fer-1 alleviated these phenotypes and ameliorated LPS-induced lung injury.