U2AF1 and cyclic hematopoiesis: However, also non-DTA mutations were detected in healthy individuals as well as in patients with myeloid neoplasm and described as CH, including aberrations in splicing factors like SRSF2, SF3B1, and U2AF1, in JAK2, or IDH2 R140Q [1, 2, 4–6] At AML diagnosis, CH-associated mutations are often found at high variant allele frequencies (VAF) and frequently persist at high VAFs in remission after chemotherapy [2, 6].