BIM, a pro-apoptotic BCL2-family protein that mediates ALK inhibitor-induced apoptosis in ALK+lung cancer cells16, was increased from 24 h to 13 days after treatment, whereas the cleaved PARP protein, which indicates apoptosis, temporarily increased 3 h after treatment, but disappeared thereafter (Fig. 1d). The gene discussed is ALK; the disease is lung carcinoma.