Furthermore, FGFR3 knockdown, but not FGFR1, prevents the cell growth of DTP cells, and cell proliferation was strongly inhibited by co-treatment with EGFR-TKI and FGFR-TKI compared with each single agent during 5 weeks treatment in all four EGFR + NSCLC cells tested including FGFR1high and FGF2low NCI-H1975. The gene discussed is FGFR3; the disease is non-small cell lung carcinoma.