FGFR1 and neoplasm: However, to suggest clinical application and analysis of FGFR1 and FGF2 protein expression in a huge number of cancer cells, we need further studies to precisely measure these protein levels in each tumor cells by a quantitative analysis using a standard curve such as ELISA, and set a specific cut-off/quantitative threshold to predict the presence or absence of combination effect with FGFR-TKIs.