Importantly, CCZ1 mutant blood vessels cells cultured as a monolayer (Fig. 7c) and, to a greater extent, bona fide blood-vessel organoids (Fig. 7d) showed a significant decrease in EBOV (monolayer: 85.25% for clone 1, 90.7% for clone 2; organoids: 99.5% for clone 1 and 2) and MARV (monolayer: 99.5% for clone 1, 99.6% for clone 2; organoids: 99.4% for clone 1 and 99.8% for clone 2) infection, visible by immunostaining (Supplementary Fig. 5), highlighting the critical role of CCZ1 in filoviruses infections in human stem cell derived blood vessels. The gene discussed is CCZ1; the disease is infection.