To address whether IDH1 mutation is involved in antiviral immunity, we first analyzed the publicly available transcriptomic datasets from 3 independent clinical cohorts, including GEO and TCGA, and found that IFN signaling pathways were downregulated in IDH1mut gliomas versus IDH1wt gliomas (Fig. 1a, b). This evidence concerns the gene IDH1 and central nervous system cancer.