Further, data analysis in the GSCA database indicated that KDM5 family members may influence the development and progression of PDAC through multiple cancer-related pathways, such as the “PI3K/AKT signaling pathway”, "EMT", "RAS/MAPK signaling pathway", "RTK signaling pathway", "apoptosis", "cell cycle", "DNA damage response signaling pathway" and "TSC/mTOR signaling pathway" (Fig. 7C). This evidence concerns the gene AKT1 and cancer.