In additional, Further analysis showed that VKORC1 was significantly associated with tumor size (P = 0.003), stage (P = 0,006), lymph node metastasis (P = 0.001), and APTT (P = 0.015), but not with sex (P = 0.528) and age (P = 0.681) (Figure S7D–I). Here, VKORC1 is linked to metastatic malignant neoplasm in the lymph nodes.