Conversely, when the expression of ESR1 was knocked down using CRISPR/Cas9, FeN4O2-SACs treatment is not able to rescue the hyperproliferation and undue inflammation of M5-induced psoriasis-like in vitro model, indicating that ESR1 is indispensable for the curative effects of FeN4O2-SACs (Supplementary Fig. 33). The gene discussed is ESR1; the disease is psoriasis.