MTHFD2 and cancer: The volcano plot in Fig. 5b highlights that mRNAs most downregulated upon mutp53 silencing were those encoding for SGOC enzymes, including PHGDH, PSAT1, MTHFD2, NNMT, and SHMT2, and for the AA transporters SLC1A4, SLC1A5, SLC3A2, and SLC7A5. These findings suggest that mutp53 plays a pivotal role in sustaining cancer cells’ adaptive response to low AA conditions.