SLC7A5 and breast cancer: To investigate the significance of SSP and LAT1-mediated AAs transport for the oncogenic function of mutp53 in BC cells, we treated MDA-MB 468 mutp53-expressing cells cultured in low AA, with NCT503 (a specific inhibitor of PHGDH, a key enzyme in the SSP), and JPH203 (a LAT1 transporter inhibitor)40.