SLC7A5 and neoplasm: As shown in Fig. 2a–c, mutp53 expression, induced by doxycycline administration, led to a significant increase in tumor volume along with enhanced expression of all SSP enzymes and transporters of EAAs and glutamine (SLC7A5, SLC3A2, and SLC1A5), and upregulation of mTORC1 signaling.