Having demonstrated that mutp53 potentiates SGOC metabolism and the import of EAAs via LAT1, we sought to identify which among the products of these pathways (i.e., nucleotides, glutathione and S-adenosylmethionine (SAM)) was critical for the survival and proliferation advantage conferred by mutp53 to cancer cells under AA restriction (Fig. 1g)10,54. Here, SLC7A5 is linked to cancer.