Bioinformatic analysis of DR5 in a gastric cancer cohort (TCGA‐STAD) showed DR5‐related up‐DEGs were involved in DNA replication and nuclear division, and down‐DEGs were involved in tight junction, which indicated DR5 in gastric cancer cells might play a role in the pathways of proliferation and metastasis. The gene discussed is TNFRSF10B; the disease is gastric cancer.