TNFRSF10B and metastatic malignant neoplasm in the lymph nodes: In our cohort of 240 gastric cancer patients, DR5 expression showed a significantly positive correlation with vascular invasion (P = 0.033), lymph node metastasis (P = 0.008), and TNM staging (P = 0.023), which indicated that DR5 might be involved in invasion and metastasis in gastric cancer.