To reveal the prognosis of DR4 and DR5 expression in gastric cancer, Kaplan–Meier curves indicated that patients with DR4‐positive expression had better overall survival (OS) outcomes (n = 136, 56.7%, P = 0.004) (Fig. 3A), but DR5‐positive expression had worse OS outcomes (n = 190, 79.2%, P = 0.006) (Fig. 3B). This evidence concerns the gene TNFRSF10B and gastric cancer.