NRF2 indeed is strongly involved in tumor growth (Rojo de la Vega et al, 2018), it can sustain and promote malignant transformation of GBM stem cells (Zhu et al, 2013) and it has been shown to be responsible for chemo and radiotherapy resistance in GBM cellular models (Singer et al, 2015; Rocha et al, 2016) shifting resistant cells towards mesenchymal phenotype (Singer et al, 2015). This evidence concerns the gene NFE2L2 and neoplasm.