Remarkably, NRF2 up-regulation in cancer can successfully face reactive oxygen species (ROS) generated by radio and chemotherapy, therefore preventing programmed cell death including ferroptosis (Wang et al, 2006; McDonald et al, 2010; Ryoo et al, 2016; Fan et al, 2017; Stockwell et al, 2017). This evidence concerns the gene NFE2L2 and cancer.