Further CellChat analysis revealed that the signaling pathways between cancer cells and identified CAFs (NRG1-ERBB2/4 and FN1-CD44/ITGAV/ITGA3/ITGB6/ITGB8/ITGB1) were specifically enriched in CAde and CSCC, respectively (Fig. 6f). The gene discussed is ITGAV; the disease is cancer.