Among the 20 most frequently used predictors, 6 (age, sex, diabetes, hypertension (as part of metabolic syndrome), blood urea nitrogen (BUN), creatinine) represent components of baseline assessment for (organ-related) infection outcomes or differential diagnoses, 10 (CRP, lactate dehydrogenase, oxygen saturation, respiratory rate, neutrophils-lymphocyte ratio, lymphopenia, dyspnea, thrombocytopenia, blood pressure, paO2/FiO2, temperature, and leukocytes) are accepted markers of overall infection severity/sepsis [29–32]. This evidence concerns the gene CRP and metabolic syndrome.