Mechanistically, the activation of nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3)‐inflammasome, and the secretion of pro-inflammatory interleukin-1β (IL-1β) are critical in the development of lipopolysaccharide (LPS)-induced ALI (4). Here, IL1B is linked to acute respiratory distress syndrome.