The CMT reduction rate 1 day afteranti-VEGF injection were also higher in the ME-RVO group than in the ME-DR group.The incidence of non-good response was significantly higher in the ME-DR groupbecause diabetes mellitus is a multifactorial, systemic disorder and thepathogenesis of diabetic macular edema (DME) is more complex(15). This evidence concerns the gene VEGFA and diabetes mellitus.