S7) showed that many of the top 20 up-regulated and down-regulated genes in CSF have roles in the organization of the cytoskeleton, response to stress, amino acid transport and metabolism, or modulation of growth factor activity, all plausible mediators of the phenotypic changes we observed in GBM cells in response to CSF (Fig. 5, A and C, and fig. This evidence concerns the gene CSF2 and glioblastoma.