We chose NUPR1 for several reasons: (i) NUPR1 is a transcription factor, so its increased expression is likely to coordinate a broad network of responses; (ii) NUPR1 was up-regulated in response to CSF in all 10 GBM cell lines we sequenced (Figs. 5A and 6, B and C); (iii) NUPR1 was a top 20 up-regulated gene in six cell lines (fig. The gene discussed is CSF2; the disease is glioblastoma.