IL4 and allergic disease: As it has been reported that IL-35 can suppress type 2 cytokine production (e.g., IL-4 and IL-5) and show a beneficial impact on allergic disease (54), we analyzed the capacity of its subunits to reduce type 2 cytokine production following stimulation with LPS and Schistosoma mansoni soluble egg antigen (SEA), a strong parasitic inflammatory trigger known to induce TH2 immune responses.