We observed that T/T (p < 0.05) and G/G homozygotes (p < 0.05), as well as heterozygotes (p < 0.05) of c.+396 T>G–IL-8 (rs2227307) SNP, were characterised by reduced IL-8 expression in the patients with urolithiasis compared with controls (Fig 4C). The gene discussed is CXCL8; the disease is urolithiasis.