Thus, the presented study was undertaken to the identification of the potential association of six SNPs in inflammation as well as nitrative and oxidative stress-related genes: IL-6 (-597 A>G, rs1800797; c.3331 G>A, rs2069845), IL-8 (c.+396 T>G, rs2227307), SOD2 (c.47 C>T; rs4880) and NOS2 (c.1823 C>T, rs2297518, g.-1026 C>A, rs2779249), and the urolithiasis occurrence. This evidence concerns the gene NOS2 and urolithiasis.