We observed that the C/T genotype of the c.47 T>C–SOD2 SNP was linked with an increased frequency of urolithiasis occurrence (OR 1.726; 1.016–2.993; 95% CI; p < 0.05) whereas the T/T homozygote of the same polymorphism decreased the risk of urolithiasis development (OR 0.489; 0.248–0.961; 95% CI; p < 0.05) in the Polish population. The gene discussed is SOD2; the disease is urolithiasis.