47 C>T–SOD2 (rs4880) and c.3331 G>A–IL-6 (rs2069845) the C/T-G/G combined genotypes were associated with an increased occurrence of urolithiasis (OR 2.707; 1.132–6.473 95% CI; p < 0.05). This evidence concerns the gene SOD2 and urolithiasis.