In contrast, the inheritance pattern of adult APS types is polygenic, involving several specific genes associated with human leukocyte antigen (HLA), cytotoxic T-lymphocyte-associated protein 4, and protein tyrosine phosphatase nonreceptor type 22, which have been linked to APS (10, 11, 12). The gene discussed is CTLA4; the disease is autoimmune polyendocrinopathy.